#1: Elizabeth ("Betty") Jean Rubble (nee McBrickle), and her best friend, Wilma Pebble Slaghoople Flintstone.
Whether they used woodpeckers' beaks or carved bone needles (which I believe was Wilma's preference), these two cavewomen were millenia ahead of their time. Most people remember Wilma and Betty as being typical stone-age hausfraus who devoted their days to vacuuming with mastodons and cleaning the breakfast dishes in their automatic pelicans. But these Bedrock babes were actually domestic trailblazers in animal skins.
Fred and Wilma were the first couple ever to be seen sharing a bed on television, and Wilma was the first cartoon character shown during pregnancy. Betty and her husband, Barney, were the first TV couple to legally adopt a child, (their son, Bamm-Bamm).
And ... no matter how badly their husbands behaved, Wilma and Betty managed to remain (mostly) level-headed. Maybe it was the knitting that kept them so calm?